Аннотация: A clinical symptom in which there is an increase in plasma glucose levels above 6.5 mmol / L on an empty stomach and 8.9 mmol / L at any time is called hyperglycemia. For hyperglycemia, a different etiological origin is possible, due to diabetes mellitus, poor nutrition and stress. The development of hyperglycemia due to the side effects of pharmacological substances cannot be ruled out. Molecular mechanisms of the development of hyperglycemia may include a decrease in the cell mass of insulocytes, followed by a slowdown in their regeneration, as well as a weakening of their functional activity. Cyclin-dependent kinases (CDK) are one of the most important factors in the proliferation and functional activity of insulocytes. Cyclin-dependent kinases are among the most important factors in the regulation of the cell cycle, cell growth and division, DNA replication and proliferation. Cyclin-dependent kinases are a family of protein serine / threonine kinases that affect the regulation of insulin expression [20, 36]. The article describes the measurements and comparison of the expression level of cyclin-dependent kinases 2,4 in pharmacological correction of hyperglycemia.
Ключевые слова: proliferation; B-endocrinocytes; hyperglycemia